Description:
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I would rather appreciate a php ini section analogous to [HOST=] querying the SAPI, e.g.

[SAPI=CLI]
extension = php-gtk2.so

in order to prevent the extension from being loaded when PHP is running as apache module or cgi. This would be helpful for distributions with like php.ini regardless of SAPI, in contrast to debian with its API-depending php.ini location.

A workaround is a modified shebang line:
#!/usr/bin/php -d extension=php_gtk2.so

but this cannot be considered a good solution.

Maybe this is not only php-gtk related.