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As described in bug #52312 - realpath cache is disabled when open_basedir is enabled. Would it be possible to either:
1) Fix the security problem related to having both enabled at the same time
2) Add a php.ini or ./configure toggle to enable both at the same time, overriding the security aspect in order to gain performance.
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I don't think the security problem is fixable. We have no way to prevent the contents behind a cache entry from changing which is the root of the security problem. And I don't see the point in open_basedir if you remove the security aspect. The less secure toggle is to simply turn off open_basedir. An open_basedir feature that doesn't actually guarantee that users can't open files outside of the specified base directory isn't useful.